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Keep track of Intently (one)pentobarbital will minimize the extent or impact of fentanyl by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Coadministration of fentanyl with CYP3A4 inducers could lead to some minimize in fentanyl plasma concentrations, deficiency of efficacy or, potentially, development of th